The need for suitable expression systems for the highly efficient and reliable production of pharmaceutical and industrial proteins is increasing continuously due to ever-growing new and generic target proteins. The selection of an appropriate and economic expression system is a crucial decision during any development. To assist you in this process we offer customer tailored studies and services:

Hansenula Feasibility Study

Aim:

• Evaluation of stable Hansenula production cell lines for your protein from an acknowledged, mature yeast system with proven industrial track record
• Evaluation of initial productivity in high cell density culture

Results and Deliverables:

• Production cell lines
• Go / No Go decision for a commercially efficient recombinant protein production from Hansenula
• Professional documentation suitable for registration purposes

Arxula Feasibility Study

Aim:

• Evaluation of stable Arxula production cell lines for your protein from a new alternative to yeast and fungal production systems
• Evaluation of initial productivity in high cell density culture

Results and Deliverables:

• Production cell lines
• Go / No Go decision for a commercially efficient recombinant protein production from Arxula
• Professional documentation suitable for registration purposes

Xplor Vector Study

Aim:

• Evaluation of several yeast species for production of your protein
• Qualitative comparison of your protein expressed from different yeast

Results and Deliverables:

• Stable recombinant yeast strains (Hansenula, Arxula, Debaryomyces, Pichia, Yarrowia a.o.)
• Data on protein processing, stability and modification

Chaperone Study

Aim:

• Improving secretion of yeast derived proteins by engineering the chaperone constitution of production cell lines

Results and Deliverables:

• Super-transformed yeast production cell line with improved secretion pathway
• Professional documentation suitable for registration purposes