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  Service and License | Artes Biotechnology GmbH

Service and License | Artes Biotechnology GmbH

Global Technology Licensing - Patent Protection and Smart Skills

In order to provide competitive production requirements, the system of choice needs a strong patent protection besides to excellent economical advantages. ARTES Biotechnology offers internationally protected systems and technologies as well as its unpatented know-how.

Your advantage: Service and license from one source

Expression Systems: Available Licenses

Research license
  • Hansenula polymorpha

Commercial license
  • Hansenula polymorpha
  • Arxula adeninivorans
  • Aspergillus sojae
  • Sordaria macrospora

Recombinant Technology: CTAB
ARTES has exclusive licensing rights in certain applications on a unique downstream processing technology for a specific protein release. Recombinant proteins located intracellularly can be specifically released by treatment with a suitable membrane extraction procedure. This method avoids mechanical cell disrupture and thus allows for facilitated purification of a soluble protein. This technology enables a commercially feasible production of intracellular enzymes from Hansenula, which are either stuck in the secretory pathway or which are unstable as secreted proteins.

Recombinant Strain: BioEthanol
ARTES Biotechnology is experienced in the genetic engineering for BioEthanol. Alpha-amylase and glucoamylase genes have been cloned from Schwanniomyces occidentalis to be transferred into established strains applied in industrial ethanol production. ARTES has access to a selected transformation protocol by which both genes can be stably integrated into the genome of any selected brewer's, distiller's or baker's yeast without inserting bacterial DNA sequences. ARTES transforms your production strain and licenses out this technology for commercial applications. Your benefit is a significant cost reduction by saving industrial enzymes or malt during BioEthanol production.

 
Research license includes a material transfer accompanied by intense training. Research licenses are uncoupled from commercialization.

The terms and conditions for commercial licenses are negotiated case by case and are adapted to client’s business. ARTES offers balanced conditions with upfront payments and royalties. Exclusive manufacturing licenses are possible.

For further information on licensing conditions please contact us.
    Recombinant Process: Hirudin
ARTES offers full process technology and know-how transfer for Hansenula derived recombinant Hirudin. The Hirudin production strain is characterized by high mitotic stability of the multi-copy expression cassettes, resulting in highly reproducible fermentation yields. The non-glycosylated and non-sulfated, biologically active protein (Desulfato-Hirudin) is secreted to the culture medium at levels of up to 1.5 g/L. The purification process results in a final product of > 98% purity. Biological activity is > 18.000 ATU/mg protein as determined by a Thrombin inhibition assay.
 
For information about the Hirudinized Universal Blood Test Tube please click here.
 
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