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In order to provide competitive production requirements, the system of choice needs a strong patent protection besides to excellent economical advantages. ARTES Biotechnology offers internationally protected systems and technologies as well as its unpatented know-how. Your advantage: Service and license from one source Expression Systems: Available Licenses Research license
Recombinant Technology: CTAB ARTES has exclusive licensing rights in certain applications on a unique downstream processing technology for a specific protein release. Recombinant proteins located intracellularly can be specifically released by treatment with a suitable membrane extraction procedure. This method avoids mechanical cell disrupture and thus allows for facilitated purification of a soluble protein. This technology enables a commercially feasible production of intracellular enzymes from Hansenula, which are either stuck in the secretory pathway or which are unstable as secreted proteins. Recombinant Strain: BioEthanol ARTES Biotechnology is experienced in the genetic engineering for BioEthanol. Alpha-amylase and glucoamylase genes have been cloned from Schwanniomyces occidentalis to be transferred into established strains applied in industrial ethanol production. ARTES has access to a selected transformation protocol by which both genes can be stably integrated into the genome of any selected brewer's, distiller's or baker's yeast without inserting bacterial DNA sequences. ARTES transforms your production strain and licenses out this technology for commercial applications. Your benefit is a significant cost reduction by saving industrial enzymes or malt during BioEthanol production. |
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| Recombinant Process: Hirudin ARTES offers full process technology and know-how transfer for Hansenula derived recombinant Hirudin. The Hirudin production strain is characterized by high mitotic stability of the multi-copy expression cassettes, resulting in highly reproducible fermentation yields. The non-glycosylated and non-sulfated, biologically active protein (Desulfato-Hirudin) is secreted to the culture medium at levels of up to 1.5 g/L. The purification process results in a final product of |
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