Hansenula - Scientific Features

Genetics:

	High stability of strains: 800 generations tested
	Multi-copy strains with up to 120 copies per cell
	Co-expression of up to 3 different genes
	Expression vectors without antibiotic resistance markers available
	Stable, high yields

Fermentation:

	Wide range of cultivation conditions: growth at 20° - 45°C, pH 2,5 - 6,0
	Simple, inexpensive media without methanol
	Short fermentation times: 70 - 120 h
	Short and flexible fermentations

Product:

	Low levels of host protein impurities upon secretion
	High productivity: 13.5 g/L obtained
	High protein stability in fermentation
	Cost effective and easy processing

Reliability:

	Approved Hansenula derived products
	High batch to batch reproducibility
	Strong patent protection
	Established technology