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Hansenula
author
title
source
year
L Guengerich, B Behle, G Gellissen, M Suckow A platform for heterologous gene expression based on the methylotrophic yeast, Hansenula polymorpha The Mycota II, Genetics and Biotechnology, 2nd edition, U Kück (Ed.) 2004
Cook MW, Thygesen HV Safety evaluation of a hexose oxidase expressed in Hansenula polymorpha Food and Chemical Toxicology 41, 523 - 529 2003
M Ramezani-Rad, CP Hollenberg, J Lauber, H Wedler, E Griess, C Wagner, K Albermann, J Hani, M Piontek, U Dahlems, G Gellissen The Hansenula polymorpha (strain CBS4732) genome sequencing and analysis FEMS Yeast Research 4, 207-215 2003
B Behle, M Billens, G Gellissen, M Piontek, E Grieß, B. Möckel Sequencing of the Hansenula polymorpha genome BIOforum international 2:88-89 2002
D Waschk, J Klabunde, M Suckow, CP Hollenberg Characteristics of the H. polymorpha genome G Gellissen (ed) Hansenula polymorpha - biology and applications, chapter 7, pp 95-104 2002
M Suckow, G Gellissen The expression platform based on Hansenula polymorpha strain RB11 and its derivatives - history, status and perspectives G Gellissen (ed) Hansenula polymorpha - biology and applications, chapter 8, pp 105-123 2002
Bartelsen, CS Barnes, G Gellissen Production of anticoagulants in Hansenula polymorpha In G Gellissen (ed) Hansenula polymorpha - biology and applications, chapter 13, pp 211-228 2002
A Papendieck, U Dahlems, G Gellissen Technical enzyme production and whole-cell biocatalysis G Gellissen (ed) Hansenula polymorpha - biology and applications, chapter 15, pp 255-271 2002
A Degelmann Methods G Gellissen (ed) Hansenula polymorpha - biology and applications, chapter 17, pp 285-335 2002
J Klabunde, A Diesel, D Waschk, G Gellissen, CP Hollenberg, M Suckow Single-step co-integration of multiple expressible heterologous genes into the ribosomal DNA of Hansenula polymorpha Appl Microbiol Biotechnol 58, 797-805 2002
KL Lahtchev, VD Semenova, II Tolstorukov, I van der Klei, M Veenhuis Isolation and properties of genetically defined strains of the methylotrophic yeast Hansenula polymorpha CBS4732 Arch Microbiol 177, 150-158 2002
S Schaefer, M Piontek, S-J Ahn, A Papendieck, ZA Janowicz, G Gellissen Recombinant Hepatitis B vaccines K Dembowsky, P Stadler (eds) Novel Therapeutic proteins - selected case studies. Wiley-VCH, Weinheim, pp 245-274 2001
CS Barnes, B Krafft, M Frech, UR Hoffmann, A Papendieck, U Dahlems, G Gellissen, MF Hoylarts Production and characterization of saratin, an inhibitor of von Willebrand factor-dependent platelet adhesion to collagen Semin Thromb Hemostas 27(4): 337-347 2001
HA Kang, W Kang, WK Hong, MW Kim, JY Kim, JH Sohn, ES Choi, KB Choe, SK Rhee Development of Expression Systems for the Production of Recombinant Human Serum Albumin Using the MOX Promoter in Hansenula polymorpha DL-1 Biotechnol Bioeng 76 (2), 175-185 2001
HA Abdel-Salam, T El-Khamissy, GA Enan, CP Hollenberg Expression of mouse anticreatine kinase (MAK33) monoclonal antibody in the yeast Hansenula polymorpha Appl Microbiol Biotechnol 56, 157-164 2001
S Krappmann, R Pries, G Gellissen, M Hiller, G Braus HARO7 encodes chorismate mutase of the methylotrophic yeast Hansenula polymorpha and is derepressed upon methanol utilization J Bacteriol 182: 4188-4197 2000
C Amuel, G Gellissen, CP Hollenberg, M Suckow Analysis of heat shock promoters in Hansenula polymorpha: TPS1, a novel element for heterologous gene expression Biotechnol Bioprocess Eng 5: 247-252 2000
N Acosta, A Beldarrain, L Rodriguez, Y Alonso Characterization of recombinant invertase expressed in methylotrophic yeasts Biotechnol Appl Biochem 32, 179-187 2000
AF Mayer, K Hellmuth, H Schlieker, R Lopez-Ulibarri, S Oertel, U Dahlems, AWM Strasser, APGM van Loon An expression system matures: A highly efficient and cost-effective process for phytase production by recombinant strains of Hansenula polymorpha Biotechnol Bioeng 63: 373-381 1999
G Gellissen, M Piontek, U Dahlems, V Jenzelewski, J Gavagan, R DiCosimo, DA Anton, ZA Janowicz Recombinant Hansenula polymorpha as a biocatalyst - coexpression of the spinach glycolate oxidase (GO) and the S. cerevisiae catalase T (CTT1) gene Appl Microbiol Biotechnol 46: 46-54 1996
H Hansen, CP Hollenberg Hansenula polymorpha (Pichia angusta) K Wolf (ed) Non-conventional yeasts in biotechnology. A handbook, Springer, Heidelberg, pp 293-311 1996
R Gatzke, U Weydemann, ZA Janowicz, CP Hollenberg Stable multicopy integration of vector sequences in Hansenula polymorpha Appl Microbiol Biotechnol 43: 844-849 1995
A Merckelbach, S Gödecke, ZA Janowicz, CP Hollenberg Cloning and sequencing of the ura3 locus of the methylotrophic yeast Hansenula polymorpha and its use for the generation of a deletion by gene replacement Appl Microbiol Biotechnol 40: 361-364 1993
G Gellissen, R Amore, CP Hollenberg Risk assessment of recombinant mircroorganism: Model studies in laboratory water and surface water samples Dechema Biotechnology Conferences 5: 809-812 1992
Z A Janowicz, K Melber, A Merckelbach, E Jacobs, N Harford, M Comberbach, CP Hollenberg Simultaneous expression of the S and L Surface Antigens of Hepatitis B, and formation of mixed particles in the methylotrophic yeast, Hansenula polymorpha Yeast 7: 431-443 1991
DL Holzschu, FW Chandler; L Ajello, DG Ahearn Evaluation of industrial yeasts for pathogenicity Sabouraudia 17, 71-78 1979



Arxula and Xplor Vector System
author
title
source
year
M Piontek, J Hagedorn, CP Hollenberg, G Gellissen, AWM Strasser Two novel gene expression systems based on the yeasts Schwanniomyces occidentalis and Pichia stipitis. Appl. Microbiol. Biotechnol 50:331-338 1998
Y Terentiev, U Breuer, W Babel, G Kunze Non-conventional yeasts as producers of polyhydroxyalkanoates – Genetic engineering of Arxula adeninivorans Appl. Microbiol. Biotechnol. 64: 376-381 2004
Y Terentiev, A.H. Pico, E Böer, T Wartmann, J Klabunde, U Breuer, W Babel, M Suckow, G Gellissen, G Kunze A wide-range integrative yeast expression vector system based on Arxula adeninivorans-derived elements J. Ind. Biotechnol. 31: 223-228 2004
E Böer, G Gellissen, G Kunze Arxula adeninivorans In: Gellissen, G. (Ed.) Production of recombinant proteins: Microbial and Eukaryotic Expression Systems. WILEY-VCH, Weinheim, pp. 89-110 2005
G Steinborn, T Wartmann, G Gellissen, G Kunze Construction of an Arxula adeninivorans host-vector system based on trp1 complementation J. Biotechnol. 127: 392-401 2007
E Böer, G Steinborn, A Matros, HP Mock, G Gellissen, G Kunze Production of interleukin-6 in Arxula adeninivorans, Hansenula polymorpha and Saccharomyces cerevisiae applying the wide range vector (CoMedTM) system to stimultaneous comparative assessment FEMS Yeast Res. 7: 1181-1187 2007
G Steinborn, G Gellissen, G Kunze A novel vector element providing multicopy vector integration in Arxula adeninivorans FEMS Yeast Res. 7: 1197-1205 2007



Expression
author
title
source
year
PJ Punt, N van Biezen, A Conesa, A Albers, J Mangnus, C van den Hondel Filamentous fungi as cell factories for heterologous protein production TRENDS in Biotechnology 20, 200-206 2002
DC Andersen, L Krummen Recombinant protein expression for therapeutic applications Curr Opinion Biotech 13, 117-123 2002
JL Cereghino, JM Cregg Heterologous protein expression in the methylotrophic yeast Pichia pastoris FEMS Microbiol Rev 24, 45-66 2000
Y Giga-Hama, H Kumagai Expression system for foreign genes using the fission yeast Schizosaccharomyces pombe Biotechnol Appl Biochem 30, 235-244 1999
M Maras, I van Die, R Contreras, CAMJJ van den Hondel Filamentous fungi as production organisms for glycoproteins of bio-medical interest Glycoconjugate Journal 16, 99-107 1999
M Piontek, J Hagedorn, CP Hollenberg, G Gellissen, AWM Strasser Two novel gene expression systems based on the yeasts Schwanniomyces occidentalis and Pichia stipitis Appl Microbiol Biotechnol 50: 331-338 1998
S Müller, T Sandal, P Kamp-Hansen, H Dalbøge Comparison of Expression Systems in the Yeasts Saccharomyces cerevisiae, Hansenula polymorpha, Kluyveromyces lactis, Schizosaccharomyces pombe and Yarrowia lipolytica. Cloning of Two Novel Promoters from Yarrowia lipolytica Yeast 14, 1267-1283 1998
G Gellissen, CP Hollenberg Applications of yeasts in gene expression - a comparison of Saccharomyces cerevisiae, Hansenula polymorpha and Kluyveromyces lactis - a review Gene 190: 87-97 1997
DB Archer, JF Peberdy The molecular biology of secreted enzyme production by fungi Crit Rev Biotech 17, 273-306 1997
J Heinisch, CP Hollenberg Yeasts H-J Rehm, G Reed, A Pühler, P Stadler (eds) Biotechnology, 2nd edition, Vol. 1, Biological fundamentals, VCH Verlagsgesellschaft, Weinheim, pp 470-514 1993
G Gellissen, K Melber, ZA Janowicz, U Dahlems, U Weydemann, M Piontek, AWM Strasser, CP Hollenberg Heterologous protein production in yeast Antonie van Leeuwenhoek Int J Gen Mol Microbiol 62: 79-93 1992



Hirudin
author
title
source
year
HD Menssen, N Brandt, R Leben , F Müller, E Thiel, K Melber Measurement of hematological, clinical chemistry and infection parameters from hirudinized blood collected in universal blood sampling tubes Sem Thromb Hemostas 27(4): 349-356 2001
GC Avgerinos, BG Turner, KJ Gorelick, A Papendieck, U Weydemann, G Gellissen Production and preclinical development of a Hansenula polymorpha-derived PEGylated hirudin Semin Thromb Hemostas 27(4): 357-371 2001
HD Menssen, K Melber, N Brandt, E Thiel The use of hirudin as universal anticoagulant in haematology, clinical chemistry and blood grouping Clin Chem Lab Med 39: 1267-1277 2001
JH Sohn, HA Kang, KJ Rao, CH Kim, ES Choi, BH Chung, SK Rhee Current status of the anticoagulant hirudin: its biotechnological production and clinical practice Appl Microbiol Biotechnol 57, 606-613 2001
U Weydemann, P Keup, M Piontek, AWM Strasser, J Schweden, G Gellissen, ZA Janowicz High-level secretion of hirudin by Hansenula polymorpha - authentic processing of three different prepro­hirudins Appl Microbiol Biotechnol 44: 377-385 1995



BioEthanol
author
title
source
year
B Hülseweh, UM Dahlems, J Dohmen, AWM Strasser, CP Hollenberg Characterization of the active site of Schwanniomyces occidentalis glucoamylase by in vitro mutagenesis Eur J Biochem 244: 128-133 1997
CP Hollenberg, AWM Strasser Improvement of baker's and brewer's yeast by gene technology Food Biotechnology 4: 527-534 1990
RJ Dohmen, AWM Strasser, UM Dahlems, CP Hollenberg Cloning of the Schwanniomyces occidentalis glucoamylase gene (GAM1) and its expression in Saccharomyces cerevisiae Gene 95: 111-121 1990
AWM Strasser, R Selk, RJ Dohmen, T Niermann, M Bielefeld, P Seeboth, G Tu, CP Hollenberg Analysis of the alpha-amylase gene of Schwanniomyces occidentalis and the secretion of its gene product in transformants of different yeast genera Eur J Biochem 184, 699-706 1989
 
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Hansenula
Arxula and Xplor Vector System
Expression
Hirudin
BioEthanol

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