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The Hansenula technology platform, as well as ARTES' other systems and technologies are protected by a number of patents covering promoters, signal sequences, chaperones as well as auxotrophic markers and integration sites. Those patents ensure complete protection for your production strain.

   
Patents:
  • MOX promoter: EP 173 378, US 5,240,838 1)
  • FMD promoter: EP 299 108, US 5,389,525 1)
  • TPS promoter: WO 00/65071 1)
  • rDNA integration: WO 01/38510 1)
  • ARO7 marker: WO 00/65071 1)
  • CMK secretion: WO 00/68400 1)
  • GAM-KEX2 leader: EP 716 705, US 5,741,674 2)
  • CHH-KEX2 leader: EP 725 822, US 5,672,487 2)
  • Glucose Fermentation Process: EP 0911416 3)
  • Xylose reductase / Xylitol dehydrogenase: EP 450 430 5)
  • Cell permeabilization: WO 01/38544 6)

New:
  • Arxula: US 10,291,304 4), WO 01/85925 1), EP 06022970.5 7),
    DE 10 2007 038 037.4 7)
  • Calnexin: EP 1 666 602 5) 1), WO 2006/053656 5) 1)
 
   Proprietor
1) Rhein Biotech
2) Rhein Biotech/BASF
3) Roche
4) ARTES/IPK
5) ARTES
6) Danisco
7) IPK
 
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